That’s pretty impressive. I hadn’t even thought oral treatments were possible!

It’s amazing.

I wish you were wrong. But…

CRISPR makes gene editing easier, but unless you’ve got a way to deliver it to every cell, it won’t do much unless you’re targeting such a small number of cells that it’s realistic to have a technician physically inject it into a cell.

That would work for an embryo. Ignoring the plethora of ethical issues and the lack of data on long-term effects, it would probably be pretty easy for a scientist to make the change in an embryo and then go through the normal in-vitro fertilization procedure.

For a whole organism, though, it’s more difficult. One obvious solution is a specially modified virus, and that’s under research.

There’s a lot of stuff here if you want to dive deep:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356196/#sec3-biomolecules-10-00839title

It’s speculation, but from my experience with Accutane I can infer the following possibility:

• an earwax blockage could get worse because of dry earwax depending on the particular ear

Also speculation:

• if there’s fewer lipids in sweat, you keep those fats, and potentially you lose less weight.

A Climate Town video convinced me natural gas actually manages to be worse.

Natural gas is methane, and it’s extremely hard to handle that without having any leaks, ever. And since methane is a very powerful greenhouse gas, it doesn’t take that much leaked gas to cross the line into “worse than coal”.

And there are lots of leaks.

Well there’s a pretty easy fix unless it’s an extreme case. Razor and antiperspirant (or just deodorant if you’re worried about aluminium).

Maybe she’s used to it. Maybe it’s not that bad to her. Or maybe she just thinks it’s impolite to point it out.

Maybe you’re right and you really don’t smell much. But most cases I’ve seen actually did smell.

For a few months, while I was taking Accutane, my earwax turned dry and flaky. It was awesome. It would come out much more easily, it wouldn’t accumulate, and for once my ears stopped producing so much liquid. But I imagine depending on your unique body, it could make things quite a bit worse if you manage to get an earwax blockage.

Disclaimer: do not take Accutane for more than a few months, unless your doctor really knows what they’re doing. Apparently there are significant risks associated with long-term usage.

And pure speculation, but I imagine if you’re not excreting that fat, you might lose a tiny bit less weight when exercising?

We can do this on isolated cells, but I really don’t think we have a way to distribute such a change across the zillions of cells in a human body.

And even if we could, it’s not clear how much effect altering the gene after the fact would have. Maybe once your apocrine glands have obeyed the gene and developed a certain way, it’s too late.

That said… Sign me the hell up.

I mean it was hardly news to begin with.

Wait they’re still adding natural gas? Geez.

Hmm, but then we’re outwardly dissing it and we can’t confidently put it in serious reporting.

And aren’t technically respectful disses the best?

I also like Xitter, because in my head that can only be pronounced Shitter, which is a good name for it.

Oh I see. Well if it has exactly the same API, if that API also has weird legacy stuff built in that hinder developers, then maybe not, but overall that does sound very similar, yes!

Yeah, that makes sense. If it’s starting to bite them in the butt, though, maybe they should start relegating that stuff to emulation, if they can write a good enough emulator.

I don’t know when. Maybe it’s already gone by, maybe it’s in the future. But there’s probably a point in time when all of that backward compatibility stops being worth it.

I don’t understand

While I haven’t diven into their codebase, that kind of thing tends to severely limit what developers can do to improve the product, slow them down, etc.

Be it new features, deeper UX improvements, performance optimizations… Basically anything you want to do with your progress, generally speaking, it’s going to get harder the more legacy stuff you need to deal with.

Not really on topic but wait just a gosh darn second.

This person is playing and reviewing (what might be called) the prettiest, most demanding game ever made, and they’re doing it on a Steam Deck, on Low?

But still, the visuals are the main thing they praise about it?

I’m a bit surprised? Confused? Anyway that’s a little weird.

My god, the amount of legacy crap in Windows.

They ought to just start over at some point.

Hey not just the EU. There are smaller initiatives in other countries, including Canada.